PDX Resource

The JAX PDX Resource contains over 450 patient-derived xenograft (PDX) models for more than 20 different cancer types which have been engrafted in immunodeficient NSG ™ mice. Models have curated clinical and patient demographic annotations, including patient treatment history. The genomes of engrafted tumors are characterized using targeted gene sequencing, transcriptional profiling, and copy number variation. Many of the models in the JAX resource have been tested for response to standard of care therapies. Features of JAX models include: 1) models generated from clinical samples, not cell lines, 2) models from diverse cancer types that reflect a spectrum of mutations/genomic configurations, and 3) genomic and dosing data based on early passage samples (> 6 passages) to retain tumor heterogeneity.... Read more

Cancer by System