LCF26: Lung Large Cell Carcinoma

Curie Institute - Lung Cancer

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Related Models
PDX model Engraftment
Host Strain Name Site Type Material Material Status Passage
Swiss Nude Crl:Nu(Ico)-foxn1nu
interscapular fat pad heterotopic tissue fragment Not Specified 10, 15, 3, 4
Not Specified Crl:NU(NCr)-Foxn1n
Not Specified Not Specified Not Specified Not Specified 15
Model Quality Control
Technique Description Passage
fingerprinting high concordance between xenograft and passage 1 3,4
histology high concordance between xenograft and patient tumour 3
Patient
Sex male
Ethnicity not specified
Derived Model LCF26
Patient Tumor Collection For PDX Model
Collection (Current Model)
Age 57
Diagnosis Lung Large Cell Carcinoma
Type primary
PDX Mouse LCF26
Collection Site lung
Grade not specified
Stage t2,n1 ( Classification: tnm staging system 2004)
Sample ID Sample Type Engrafted Tumor Passage Data Type Data Available Platform Used Raw Data
LCF26p3:23/09/2011 Engrafted Tumor Passage 3 copy number alteration View data CGH array Not Available
LCF26p15:11/04/2018 Engrafted Tumor Passage 15 cytogenetics View data FISH Not Available
LCF26p10:28/06/2016 Engrafted Tumor Passage 10 mutation View data Targeted NGS Not Available

Sample ID:     Histology:     Tumor Type: Engrafted Tumor     Passage:     Platform:    

Dosing study protocol
Drug Dose Response
Cisplatin and Paclitaxel 20mg/kg + 4mg/kg / 20mg/kg + 4mg/kg partial response
Cisplatin and Pemetrexed 100mg/kg + 4mg/kg / 100mg/kg + 4mg/kg stable disease
Cisplatin 1.0mg/kg stable disease
Cisplatin 6.0mg/kg stable disease
Cisplatin and Paclitaxel 20mg/kg + 4mg/kg / 20mg/kg + 4mg/kg partial response