253994-281-T: Colorectal Cancer

Patient-Derived Models Repository


Patient
Sex Male
Age at Time of Collection 37
Race / Ethnicity / Not Hispanic or Latino
Patient Tumor
Histology Colorectal Cancer
Primary Tissue Digestive/Gastrointestinal
Collection Site Not Specified
Tumor Type Metastatic
Grade Low grade ( Classification: )
Stage Not Specified
PDX model Engraftment
Host Strain Name Site Type Material Material Status Passage
NOD scid gamma Subcutaneous (flank) Heterotopic Not Specified Not Specified 0, 1, 2, 3, 4, Not Specified
Model Quality Control
Technique Description Passage
Histology Model validated against histological features of same diagnosis All
Fingerprinting Model validated against patient tumour or P0 xenograft All
Human mouse/DNA Model validated against patient tumour or P0 xenograft All
Collection (Current Model)
Age 37
Diagnosis Colorectal Cancer
Type Metastatic
PDX Mouse 253994-281-T
Collection Site Not Specified
Sex Male
Race / Ethnicity Not specified / Not Hispanic or Latino
Date Regimen Started Regimen Dose Best Response Duration (Months)
2014-07-01 Fluorouracil Not Specified Disease Progression null Months
2014-10-01 Fluorouracil and Irinotecan and Leucovorin and Ziv-Aflibercept Not Specified Disease Progression 3 Months / 3 Months / 3 Months / 3 Months
2015-08-01 Regorafenib Not Specified Disease Progression 1 Months
2013-11-01 Bevacizumab and Fluorouracil and Leucovorin Not Specified Disease Progression 8 Months / 8 Months / 8 Months
2015-05-01 Bevacizumab and Capecitabine Not Specified Disease Progression 1 Months / 1 Months
2015-06-01 Sorafenib Not Specified Disease Progression 2 Months
2015-04-01 Regorafenib Not Specified Disease Progression 1 Months
2014-07-01 Bevacizumab and Fluorouracil and Leucovorin Not Specified Disease Progression 1 Months / 1 Months / 1 Months
2015-01-01 Bevacizumab and Fluorouracil and Leucovorin Calcium and Oxaliplatin Not Specified Disease Progression 3 Months / 3 Months / 3 Months / 3 Months
2014-05-01 Bevacizumab Not Specified Disease Progression 1 Months
2013-06-01 Bevacizumab and Fluorouracil and Leucovorin Calcium and Oxaliplatin Not Specified Disease Progression 5 Months / 5 Months / 5 Months / 5 Months
2015-08-01 Capecitabine Not Specified Disease Progression 1 Months
Sample ID Sample Type Engrafted Tumor Passage Data Type Data Available Platform Used Raw Data
E85M207E17 Engrafted Tumor Passage 2 mutation View data NCI cancer gene panel NCI cancer gene panel Not available
E85M208 Engrafted Tumor Passage 1 mutation View data NCI cancer gene panel NCI cancer gene panel Not available
E85M209EE3F36A35 Engrafted Tumor Passage 4 mutation View data NCI cancer gene panel NCI cancer gene panel Not available
E85M209 Engrafted Tumor Passage 1 mutation View data NCI cancer gene panel NCI cancer gene panel Not available

Sample ID:     Histology:     Tumor Type: Engrafted Tumor     Passage:     Platform: