743489-274-T: Clear Cell Renal Cell Carcinoma

Patient-Derived Models Repository


Patient
Sex Male
Age at Time of Collection 37
Race / Ethnicity / Not Hispanic or Latino
Related models 743489-281-T
Patient Tumor
Histology Clear Cell Renal Cell Carcinoma
Primary Tissue Genitourinary
Collection Site Not Specified
Tumor Type Metastatic
Grade Intermediate grade ( Classification: )
Stage Not Specified
PDX model Engraftment
Host Strain Name Site Type Material Material Status Passage
NOD scid gamma Subcutaneous (flank) Heterotopic Not Specified Not Specified 0, 1, Not Specified
Model Quality Control
Technique Description Passage
Histology Model validated against histological features of same diagnosis All
Human mouse/DNA Model validated against patient tumour or P0 xenograft All
Fingerprinting Model validated against patient tumour or P0 xenograft All
Collection (Current Model) Collection (Other Model)
Age 37 37
Diagnosis Clear Cell Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma
Type Metastatic Metastatic
PDX Mouse 743489-274-T 743489-281-T
Collection Site Not Specified Not Specified
Sex Male
Race / Ethnicity Not specified / Not Hispanic or Latino
Date Regimen Started Regimen Dose Best Response Duration (Months)
2013-03-01 Indotecan Not Specified Stable Disease 3 Months
2012-08-01 capecitabine and Bevacizumab and Gemcitabine Not Specified Stable Disease 5 Months / 5 Months / 5 Months
2012-04-01 Sunitinib Malate Not Specified Disease Progression 3 Months
2012-08-01 everolimus Not Specified Disease Progression 1 Months
2013-10-01 (Current) Pazopanib Hydrochloride and Tivantinib Not Specified Stable Disease Not Specified / Not Specified
Sample ID Sample Type Engrafted Tumor Passage Data Type Data Available Platform Used Raw Data
J13JP3 Engrafted Tumor Passage 1 mutation View data NCI cancer gene panel NCI cancer gene panel Not available
J11JR7 Engrafted Tumor Passage 1 mutation View data NCI cancer gene panel NCI cancer gene panel Not available
J11K93 Engrafted Tumor Passage 1 mutation View data NCI cancer gene panel NCI cancer gene panel Not available
J12 Engrafted Tumor Passage 0 mutation View data NCI cancer gene panel NCI cancer gene panel Not available

Sample ID:     Histology:     Tumor Type: Engrafted Tumor     Passage:     Platform: